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首页-小分子抑制剂&激动剂-GPCR-Orexin Receptor-RTOXA-43
RTOXA-43

Chemical Structure : RTOXA-43

CAS No.: 2832067-72-6

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RTOXA-43 (RTOXA43)

货号: PC-20563Not For Human Use, Lab Use Only.

RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RTOXA-43 is a potent, dual orexin receptor agonist with EC50 of 24 nM at both OX2R and OX1R.
    RTOXA-43 (40 mg/kg, i.p.) increased time awake, decreased time asleep and increased sleep/wake consolidation when measured using continuous EEG/EMG recordings in 12-month old mice.

    物理化学性质&存储条件

    分子量 663.79
    分子式 C37H37N5O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4'-methoxy-N-methyl-3'-(N-(3-((2-(3-methylbenzamido)ethyl)amino)phenyl)sulfamoyl)-N-(pyridin-4-ylmethyl)-[1,1'-biphenyl]-3-carboxamide

    参考文献

    1. Dehui Zhang, et al. J Med Chem. 2021 Jun 24;64(12):8806-8825.

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