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首页-小分子抑制剂&激动剂-GPCR-GPR88-RTI-122
RTI-122

Chemical Structure : RTI-122

CAS No.: 3034664-39-3

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RTI-122 (RTI 122)

货号: PC-20278Not For Human Use, Lab Use Only.

RTI-122 (RTI 122) is a highly potent, selective and brain permeable GPR88 agonist with cAMP EC50 of 11 nM (hGPR88 CHO).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RTI-122 (RTI 122) is a highly potent, selective and brain permeable GPR88 agonist with cAMP EC50 of 11 nM (hGPR88 CHO).
    RTI-122 shows good metabolic stability (half-life of 5.8 h) and brain permeability (brain/plasma ratio of >1) in mice.
    RTI-122 is more effective than RTI-13951-33 (Cat# PC-35398) in attenuating the binge-like alcohol drinking behavior in the drinking-in-the-dark paradigm.

    物理化学性质&存储条件

    分子量 491.61
    分子式 C29H34FN3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R)-N-((2R,3R)-2-amino-3-methoxybutyl)-2-(5-fluoropyridin-2-yl)-N-(4'-isopropoxy-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxamide

    参考文献

    1. Md Toufiqur Rahman, et al. J Med Chem. 2023 Feb 23;66(4):2964-2978.

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