RTI-118 | NPSR antagonist | Probechem Biochemicals

Chemical Structure : RTI-118

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RTI-118 (RTI 118)

货号: PC-21472Not For Human Use, Lab Use Only.

RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.

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1 g		Get quote

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生物&药学活性

RTI-118 is a potent, selective neuropeptide S receptor (NPSR, GPR154) antagonist.
RTI-118 (5–30 mg/kg i.p.) produced a dose-dependent and nearly complete elimination of cocaine self-administration, and was more potent and efficacious to reduce cocaine self-administration than food-maintained responding.
RTI-118 (1–20 mg/kg i.p.) also blocked cocaine, cue-, and stress-induced reinstatement of extinguished cocaine self-administration.

物理化学性质&存储条件

分子量	448.57
分子式	C26H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-oxo-1,1-diphenyl-N-(2-(piperidin-1-yl)ethyl)tetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide

参考文献

1. Zhang Y, et al. Bioorg Med Chem Lett. 2008;18:4064–4067.

2. Julie S Bonano, et al. Eur J Pharmacol. 2014 Nov 15:743:98-105.

3. Christopher D Schmoutz, et al. Pharmacol Biochem Behav. 2012 Dec;103(2):332-7.

RTI-118 (RTI 118)

生物&药学活性

物理化学性质&存储条件

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RTI-118 (RTI 118)

生物&药学活性

物理化学性质&存储条件

参考文献

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