RTA-408 (Omaveloxolone, RTA408)

Chemical Structure : RTA-408

CAS No.: 1474034-05-3

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货号: PC-42916Not For Human Use, Lab Use Only.

RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators.
RTA-408 dose-dependently reduces NO concentrations with IC50 value of 4.4±1.8 nM in RAW 264.7 cells。
RTA-408 also increases p21 levels and JNK phosphorylation.

物理化学性质&存储条件

分子量	554.7109
分子式	C33H44F2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-

参考文献

1. Probst BL, et al. PLoS One. 2015 Apr 21;10(4):e0122942.

2. Liu X, et al. Redox Biol. 2016 Aug;8:98-109.

3. Nakagami Y, et al. J Radiat Res. 2016 Sep;57(5):567-571.