RSV inhibitor compound 1 |CAS:1422496-79-4 Probechem Biochemicals

Chemical Structure : RSV inhibitor compound 1

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RSV inhibitor compound 1 (RSV fusion inhibitor)

货号: PC-35761Not For Human Use, Lab Use Only.

RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM).

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生物&药学活性

RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM).
RSV inhibitor compound 1 demonstrats single-digit nM anti-RSV activity against different RSV strains (RSV A2, RSV B with EC50 of 4 and 2 nM).
RSV inhibitor compound 1 also displays 1 log viral reduction in a female BALB/c mice RSV model by b.i.d. oral dosing at 12.5 mg/kg.

物理化学性质&存储条件

分子量	438.546
分子式	C23H26N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3-Aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-amine

参考文献

1. Zheng X, et al. J Med Chem. 2018 Nov 2. doi: 10.1021/acs.jmedchem.8b01394.

RSV inhibitor compound 1 (RSV fusion inhibitor)

生物&药学活性

物理化学性质&存储条件

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RSV inhibitor compound 1 (RSV fusion inhibitor)

生物&药学活性

物理化学性质&存储条件

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