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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-RSVA405
RSVA405

Chemical Structure : RSVA405

CAS No.: 140405-36-3

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RSVA405 (RSVA 405, RSVA-405)

货号: PC-47019Not For Human Use, Lab Use Only.

RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM.
RSVA405 inhibited 3T3-L1 adipocyte differentiation by interfering with mitotic clonal expansion during preadipocyte proliferation with IC50 of 0.5 uM.
RSVA405 prevented the adipogenesis-dependent transcriptional changes of multiple gene products involved in the adipogenic process, including PPARγ, CCAAT/enhancer-binding protein α (C/EBPα), fatty acid synthase, fatty acid binding protein 4 (aP2), RANTES or resistin.
RSVA405 (20 and 100 mg/kg/d, oral) significantly reduced the body weight gain of mice fed a high-fat diet.
RSVA405 potently inhibited both constitutive and stimulated STAT3 activity in HEK293 cells and LPS-stimulated RAW 264.7 macrophages, respectively.

物理化学性质&存储条件

分子量 312.37
分子式 C17H20N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

参考文献

1. Vingtdeux V, et al. Mol Med. 2011 Sep-Oct;17(9-10):1022-30.

2. Capiralla H, et al. FEBS J. 2012 Oct;279(20):3791-9.

3. Vingtdeux V, et al. FASEB J. 2011 Jan;25(1):219-31.

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