RSV604 |CAS:676128-63-5 Probechem Biochemicals

Chemical Structure : RSV604

CAS No.: 676128-63-5

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RSV604 (RSV-604)

货号: PC-43309Not For Human Use, Lab Use Only.

RSV604 (RSV-604) is a potent respiratory syncytial virus (RSV) inhibitor with EC50 of 0.86 uM in XTT assay, targets the nucleocapsid protein and is active post-RSV infection.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2680	In stock
100 mg		Get quote

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生物&药学活性

RSV604 (RSV-604) is a potent respiratory syncytial virus (RSV) inhibitor with EC50 of 0.86 uM in XTT assay, targets the nucleocapsid protein and is active post-RSV infection.
RSV604 is also equipotent against 40 clinical isolates of RSV with an average EC50 of 0.8 μM by plaque reduction assay.
The mutations (N105D, I129L, L139I, and I129L with L139I) within the nucleocapsid protein confer 5->20-fold reduced potentcy for RSV604.
RSV604 inhibits virus replication after mucosal inoculation in human airway epithelial cell model (EC50=0.5-0.9 uM).

物理化学性质&存储条件

分子量	388.3944
分子式	C22H17FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 195 mg/mL
Chemical Name/SMILES	Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-

参考文献

1. Henderson EA, et al. J Med Chem. 2007 Apr 5;50(7):1685-92.

2. Chapman J, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53.

3. Challa S, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.

RSV604 (RSV-604)

生物&药学活性

物理化学性质&存储条件

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RSV604 (RSV-604)

生物&药学活性

物理化学性质&存储条件

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