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RSMI-29

Chemical Structure : RSMI-29

CAS No.: 326911-66-4

RSMI-29 (RSMI 29)

货号: PC-22182Not For Human Use, Lab Use Only.

RSMI-29 is a small molecule inhibitor of ricin toxin, specifically targeting ricin toxin A chain (RTA) with binding KD of 0.9 uM, inhibits cytotoxicity of RTA/ricin.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RSMI-29 is a small molecule inhibitor of ricin toxin, specifically targeting ricin toxin A chain (RTA) with binding KD of 0.9 uM, inhibits cytotoxicity of RTA/ricin.
RSMI-29 attenuates RTA/ricin-induced protein synthesis inhibition and rRNA depurination.
RSMI-29 (0.15 mg/kg) protects mice against ricin intoxication, reduces ricin-induced organ damage.

物理化学性质&存储条件

分子量 367.38
分子式 C14H17N5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N-diethyl-3-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)benzenesulfonamide

参考文献

1. Xinran Yang, et al. Molecules. 2024 Mar 22;29(7):1435.

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