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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-RSK2-IN-20
RSK2-IN-20

Chemical Structure : RSK2-IN-20

CAS No.: 1627136-55-3

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RSK2-IN-20

货号: PC-62854Not For Human Use, Lab Use Only.

RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM.
    RSK2-IN-20 shows high selectivity over NEK2, PLK1.
    RSK2-IN-20 potently inhibits MSK1 autophosphorylation in cells, and has no significant effect on a panel of 18 additional kinases.

    物理化学性质&存储条件

    分子量 402.414
    分子式 C21H18N6O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(1H-1,2,4-triazol-1-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylonitrile

    参考文献

    1. Krishnan S, et al. J Am Chem Soc. 2014 Sep 10;136(36):12624-30.

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