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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-RS504393
RS504393

Chemical Structure : RS504393

CAS No.: 300816-15-3

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RS504393 (RS-504393)

货号: PC-23688Not For Human Use, Lab Use Only.

RS504393 is a potent, selective CCR2 antagonist with IC50 of 89 nM, shows no activity against CCR1.

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5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RS504393 is a potent, selective CCR2 antagonist with IC50 of 89 nM, shows no activity against CCR1.
RS504393 reduced renal interstitial fibrosis relative to wild-type mice.
RS504393 attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
RS504393 significantly inhibited the expression of CCR1, CCR2 and interleukin (IL)-8 after either LPS or tumor necrosis factor-alpha stimulation in A549 cells,.
RS504393 improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice.

物理化学性质&存储条件

分子量 417.51
分子式 C25H27N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

参考文献

1. Kitagawa K, et al. Am J Pathol. 2004 Jul;165(1):237-46.

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