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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-RAD51-RS-35d
RS-35d

Chemical Structure : RS-35d

CAS No.:

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RS-35d (RAD51-BRCA2 inhibitor 35d)

货号: PC-24243Not For Human Use, Lab Use Only.

RS-35d (RAD51-BRCA2 inhibitor 35d) is a small molecule inhibitor of BRCA2-RAD51 with EC50 of 19 uM in ELISA assays, binds to RAD51 with Kd of 11 uM, disrupts the RAD51-BRCA2 protein-protein interaction, thus mimicking the effect of BRCA2 mutation.

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10 mg ￥2280 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RS-35d (RAD51-BRCA2 inhibitor 35d) is a small molecule inhibitor of BRCA2-RAD51 with EC50 of 19 uM in ELISA assays, binds to RAD51 with Kd of 11 uM, disrupts the RAD51-BRCA2 protein-protein interaction, thus mimicking the effect of BRCA2 mutation.
RS-35d inhibits the homologous recombination in a human pancreatic adenocarcinoma cell line.
RS-35d synergizes with olaparib (a PARPi) to trigger synthetic lethality.

物理化学性质&存储条件

分子量 485.97
分子式 C28H24ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Chloro-3-(5-(4-methoxyphenyl)-1-propionyl-4,5-dihydro-1H-pyrazol-3-yl)-4-phenylquinolin-2(1H)-one

参考文献

1. Bagnolini G, et al. J Med Chem. 2020 Mar 12;63(5):2588-2619.

2. Masi M, et al. Cell Death Discov. 2025 Mar 16;11(1):106.

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