RS-1748 | CCR4 antagonist | Probechem Biochemicals

Chemical Structure : RS-1748

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RS-1748 (RS1748)

货号: PC-73265Not For Human Use, Lab Use Only.

RS-1748 is a highly potent, selective, orallu active CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM.

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生物&药学活性

RS-1748 is a highly potent, selective, orallu active CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 59.9 nM.
RS-1748 displays no competitive displacement in the binding of [125I]CCL3 (MIP-1α) to CCR1 and [125I]CCL2 (MCP-1) to CCR2b. dose-dependently inhibited 50 nM CCL22-induced [Ca2+]i mobilization with IC50 of 28.3 nM, inhibited the binding of [35S]GTPgS to human CCR4-expressing CHO cells with IC50 of 18.4 nM.
Orally administered RS-1748 (30 mg/kg) significantly lowered the total cell numbers and the eosinophils numbers in ovalbumin-sensitized guinea pigs.

物理化学性质&存储条件

分子量	430.475
分子式	C23H25F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-(diethylamino)ethoxy)phenyl)-N-(2,4-difluorobenzyl)-5-fluoropyrimidin-4-amine

参考文献

1. Nakagami Y,, et al. Biol Pharm Bull. 2010;33(6):1067-9.

RS-1748 (RS1748)

生物&药学活性

物理化学性质&存储条件

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RS-1748 (RS1748)

生物&药学活性

物理化学性质&存储条件

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