RS-1269 | CCR4 antagonist | Probechem Biochemicals

Chemical Structure : RS-1269

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RS-1269 (RS1269)

货号: PC-73264Not For Human Use, Lab Use Only.

RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM.

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生物&药学活性

RS-1269 is a highly potent, selective CCR4 antagonist, inhibits [125I]CCL17 binding to human CCR4 with IC50 of 27.7 nM.
RS-1269 also has strong affinity to displace the CCL17 binding with IC50 of 27.0 nM in CCR4-expressing CHO cells.
RS-1269 displays no competitive displacement in the binding of [125I]CCL3 (MIP-1α) to CCR1 and [125I]CCL2 (MCP-1) to CCR2b.
RS-1269 dose-dependently inhibited CCL17-induced migration of Th2 cells with IC50 of 5.5 nM.
Orally administered RS-1269 (30 mg/kg) ameliorates ovalbumin-induced ear swelling in mice.
RS-1269 also inhibited LPS-induced TNF-α production in vivo.

物理化学性质&存储条件

分子量	562.714
分子式	C35H38N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(isobutyrylamino)-N-{2-[(2R)-2-phenyl-4-(4-pyridin-4-ylbenzyl)morpholin-2-yl]ethyl}benzamide

参考文献

1. Nakagami Y, et al. Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):793-7.

RS-1269 (RS1269)

生物&药学活性

物理化学性质&存储条件

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RS-1269 (RS1269)

生物&药学活性

物理化学性质&存储条件

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