RS-102221 | 5-HT2C antagonist | Probechem Biochemicals

Chemical Structure : RS-102221

CAS No.: 187397-18-8

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RS-102221 (RS102221)

货号: PC-60815Not For Human Use, Lab Use Only.

RS-102221 is a highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

RS-102221 is a highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively.
RS-102221 demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors.
RS-102221 acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.).
RS-102221 reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.

物理化学性质&存储条件

分子量	649.08
分子式	C27H31F3N4O7S.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride

参考文献

1. Bonhaus DW, et al. Neuropharmacology. 1997 Apr-May;36(4-5):621-9.

2. Bonhaus DW, et al. Ann N Y Acad Sci. 1998 Dec 15;861:269.

3. Sévoz-Couche C, et al. Br J Pharmacol. 2000 Dec;131(7):1445-53.

4. McMahon LR, et al. J Neurosci. 2001 Oct 1;21(19):7781-7.

RS-102221 (RS102221)

生物&药学活性

物理化学性质&存储条件

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RS-102221 (RS102221)

生物&药学活性

物理化学性质&存储条件

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