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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-RR601
RR601

Chemical Structure : RR601

CAS No.: 1970119-63-1

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RR601 (RR 601, RR-601)

货号: PC-61175Not For Human Use, Lab Use Only.

RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 uM and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RR601 is a potent, selective protein tyrosine phosphatase DUSP5, PTP1B and SHP-2 inhibitor with IC50 of 36 uM, 2.1 uM and 1.1 uM respectively, 8-fold selectivity for PTP1B versus DUSP5.
    RR601 has IC50 of 4.8 uM in pERK assays.

    物理化学性质&存储条件

    分子量 518.422
    分子式 C20H12N2Na2O8S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    sodium (E)-8,8'-(diazene-1,2-diyl)bis(4-hydroxynaphthalene-2-sulfonate)

    参考文献

    1. Bongard RD, et al. BMC Biochem. 2017 May 31;18(1):10.

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