RPR260243 |CAS:668463-35-2 Probechem Biochemicals

Chemical Structure : RPR260243

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RPR260243 (RPR 260243;RPR-260243)

货号: PC-60839Not For Human Use, Lab Use Only.

RPR260243 is a potent, selective hERG potassium channel (Kv11.1) activator that dramatically slows current deactivation at 1-30 uM.

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生物&药学活性

RPR260243 is a potent, selective hERG potassium channel (Kv11.1) activator that dramatically slows current deactivation at 1-30 uM.
RPR260243-modified HERG currents is inhibited by dofetilide (IC50=58 nM), has little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes, and no activator-like effects on other voltage-dependent ion channels, including the erg3 K+ channel.
RPR260243 completely reverses the action potential-prolonging effects of dofetilide in guinea pig myocytes.

物理化学性质&存储条件

分子量	510.513
分子式	C28H25F3N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid

参考文献

1. Kang J, et al. Mol Pharmacol. 2005 Mar;67(3):827-36.

RPR260243 (RPR 260243;RPR-260243)

生物&药学活性

物理化学性质&存储条件

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RPR260243 (RPR 260243;RPR-260243)

生物&药学活性

物理化学性质&存储条件

参考文献

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