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首页-小分子抑制剂&激动剂-Others-Other Targets-RPI-194
RPI-194

Chemical Structure : RPI-194

CAS No.:

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RPI-194 (RPI194)

货号: PC-47074Not For Human Use, Lab Use Only.

RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I.

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5 mg ￥2280 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RPI-194 is a novel troponin activator that binds to cardiac/slow skeletal muscle troponin, binds to cardiac troponin with KD of 24 uM, stabilizing the activated complex between troponin C and the switch region of troponin I.
RPI-194 shows no effect on the ATPase activity of purified actin-myosin.
RPI-194 markedly decreased the velocity and amplitude of contractions in isolated unloaded mouse cardiomyocytes.
RPI-194 acts as a calcium sensitizer in all striated muscle types.

物理化学性质&存储条件

分子量 323.776
分子式 C19H14ClNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2'-((3-chlorophenyl)amino)-[1,1'-biphenyl]-4-carboxylic acid

参考文献

1. Zabed Mahmud, et al. Front Physiol. 2022 Jun 8;13:892979.

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