RORγt inverse agonist 32

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-RORγt inverse agonist 32

Chemical Structure : RORγt inverse agonist 32

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货号: PC-35570Not For Human Use, Lab Use Only.

RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays.
RORγt inverse agonist 32 inhibits IL-17 production from human primary TH17 cells with IC50 of 57 n.
RORγt inverse agonist 32 also exhibits favorable PK in rodents.

物理化学性质&存储条件

分子量	515.574
分子式	C24H22FN3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Acetamido-N-[4-(5-cyano-3-fluoro-2-methoxy-phenyl)-2-thienyl]-2-(4-ethylsulfonylphenyl)acetamide

参考文献

1. Narjes F, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b00783.

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