RORγt inverse agonist 22 |CAS:1644029-01-5 Probechem Biochemicals

Chemical Structure : RORγt inverse agonist 22

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RORγt inverse agonist 22

货号: PC-35413Not For Human Use, Lab Use Only.

RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.
RORγt inverse agonist 22 exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors。
RORγt inverse agonist 22 demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.

物理化学性质&存储条件

分子量	489.551
分子式	C23H25F2N3O5Si
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-1-(4-methoxyphenyl)-2-oxoethyl)-3-hydroxy-N-methylisoxazole-5-carboxamide

参考文献

1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500.