RORγt inverse agonist 1 |CAS:2079892-79-6 Probechem Biochemicals

Chemical Structure : RORγt inverse agonist 1

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RORγt inverse agonist 1

货号: PC-60487Not For Human Use, Lab Use Only.

RORγt inverse agonist 1 is a potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RORγt inverse agonist 1 is a potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays.
RORγt inverse agonist 1 shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ.
RORγt inverse agonist 1 attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays.

物理化学性质&存储条件

分子量	475.597
分子式	C26H33N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(8-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-methylpyrimidine-5-carboxamide

参考文献

1. Guendisch U, et al. PLoS One. 2017 Nov 20;12(11):e0188391.

2. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648.