RORγt-IN-9a | RORγt inhibitor | Probechem Biochemicals

Chemical Structure : RORγt-IN-9a

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RORγt-IN-9a (RORγt inhibitor 9a)

货号: PC-60488Not For Human Use, Lab Use Only.

RORγt-IN-9a is a potent, selective, CNS penetrant, orally bioavailable RORγt inhibitor with pIC50 of 8.3 in FRET assays.

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生物&药学活性

RORγt-IN-9a is a potent, selective, CNS penetrant, orally bioavailable RORγt inhibitor with pIC50 of 8.3 in FRET assays.
RORγt-IN-9a has TH17 pEC50 of 7.3, demonstrates excellent in vivo efficacy in EAE mice.

物理化学性质&存储条件

分子量	518.328
分子式	C22H16Cl2F3NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(methylsulfonyl)phenyl)acetamide

参考文献

1. Wang Y, et al. ACS Med Chem Lett. 2015 May 26;6(7):787-92.

RORγt-IN-9a (RORγt inhibitor 9a)

生物&药学活性

物理化学性质&存储条件

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RORγt-IN-9a (RORγt inhibitor 9a)

生物&药学活性

物理化学性质&存储条件

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