ROMK-IN-32 |CAS:1914944-54-9 Probechem Biochemicals

Chemical Structure : ROMK-IN-32

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ROMK-IN-32

货号: PC-62832Not For Human Use, Lab Use Only.

ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.

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生物&药学活性

ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.
ROMK-IN-32 shows an improved functional hERG/ROMK potency ratio (1176x) and preclinical PK profile.
ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model.

物理化学性质&存储条件

分子量	452.511
分子式	C24H28N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-8-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)-2-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one

参考文献

1. Dong S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566.

ROMK-IN-32

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物理化学性质&存储条件

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ROMK-IN-32

生物&药学活性

物理化学性质&存储条件

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