ROMK-IN-25 |CAS:1443735-02-1 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ROMK-IN-25

Chemical Structure : ROMK-IN-25

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ROMK-IN-25

货号: PC-62794Not For Human Use, Lab Use Only.

ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM.
ROMK-IN-25 displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles.
ROMK-IN-25 does not evoke QTc prolongation in an in vivo cardiovascular dog model.

物理化学性质&存储条件

分子量	462.489
分子式	C23H23FN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3R,9aS)-8-(2-(5-(1H-tetrazol-1-yl)pyridin-2-yl)acetyl)octahydropyrazino[2,1-c][1,4]oxazin-3-yl)-6-fluoro-2-methylbenzonitrile

参考文献

1. Zhu Y, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702.

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ROMK-IN-25

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物理化学性质&存储条件

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ROMK-IN-25

生物&药学活性

物理化学性质&存储条件

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