ROF2 | Amyloid probe | Probechem Biochemicals

Chemical Structure : ROF2

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ROF2 (ROF-2)

货号: PC-22406Not For Human Use, Lab Use Only.

ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.

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生物&药学活性

ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.
ROF2 dispalys superior sensing capability in monitoring, detecting, and distinguishing amyloid aggregates of different sequences (Amyloid-β, human islet amyloid polypeptide, or human calcitonin) and sizes (monomers, oligomers, or fibrils), compared with Thioflavin T (ThT).
ROF2 exhibits the aggregation- and concentration-dependent emissive property for amyloid detection.
ROF2 (0.2 uM) is sufficiently effective in detecting amyloid aggregates, induces significant fluorescence upon binding to amyloid aggregates.

物理化学性质&存储条件

分子量	485.60
分子式	C29H27NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(4-(methylsulfonyl)phenyl)-3-phenyl-5-(2-(piperidin-1-yl)benzylidene)furan-2(5H)-one

参考文献

1. Tang Y, et al. Small. 2024 May 15:e2400879.

ROF2 (ROF-2)

生物&药学活性

物理化学性质&存储条件

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ROF2 (ROF-2)

生物&药学活性

物理化学性质&存储条件

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