ROC-325 | Autophagy inhibitor | Probechem Biochemicals

Chemical Structure : ROC-325

CAS No.: 1859141-26-6

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ROC-325 (ROC 325, ROC325)

货号: PC-60599Not For Human Use, Lab Use Only.

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
ROC-325 exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux.
ROC-325 antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity.
ROC-325 significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.

物理化学性质&存储条件

分子量	503.061
分子式	C28H27ClN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

参考文献

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.

2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

ROC-325 (ROC 325, ROC325)

生物&药学活性

物理化学性质&存储条件

参考文献

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ROC-325 (ROC 325, ROC325)

生物&药学活性

物理化学性质&存储条件

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