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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-RO9021
RO9021

Chemical Structure : RO9021

CAS No.: 1446790-62-0

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RO9021 (RO 9021;RO9021)

货号: PC-45082Not For Human Use, Lab Use Only.

RO9021 is an orally bioavailable, ATP-competitive, highly selective inhibitor of Syk kinase with IC50 of 5.6 nM.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RO9021 is an orally bioavailable, ATP-competitive, highly selective inhibitor of Syk kinase with IC50 of 5.6 nM.
RO9021 suppresses BCR signaling in hPBMC and FcγR signaling in human monocytes.
RO9021 blocks osteoclastogenesis from mouse bone marrow macrophages in vitro, also inhibits TLR9 signaling in human Bcells.
RO9021 also potently inhibits type I interferon production by human plasmacytoid dendritic cells (pDC) upon TLR9 activation, inhibits arthritis progression in the mCIA model.

物理化学性质&存储条件

分子量 355.4374
分子式 C18H25N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: < 3.6 mg/mL
Chemical Name/SMILES

3-Pyridazinecarboxamide, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-

参考文献

1. Liao C, et al. Arthritis Res Ther. 2013 Oct 4;15(5):R146.

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