RO7185876 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : RO7185876

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RO7185876 (RO 7185876)

货号: PC-72151Not For Human Use, Lab Use Only.

RO7185876 (RO 7185876) is a potent and selective γ-secretase modulator (GSM) with IC50 Aβ42 of 2 nM.

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生物&药学活性

RO7185876 (RO 7185876) is a potent and selective γ-secretase modulator (GSM) with IC50 Aβ42 of 2 nM.
RO7185876 demonstrates an excellent in vitro and in vivo DMPK profile, does not inhibit the Notch pathway,
RO7185876 reduced the amount of the large peptides Aβ42 and Aβ40 prone to aggregate and increases the fractions of smaller peptides Aβ37 and Aβ38 while leaving the total amount of Aβ unchanged.
RO7185876 demonstrated Aβ42 reduction effect in double transgenic mice model APP-Sweddish (free in vivo IC50 Aβ42=2.5 nM).

物理化学性质&存储条件

分子量	472.516
分子式	C24H27F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-Methyl-4-pyrimidinyl)-N-[(9S)-6,7,8,9-tetrahydro-9-(2,3,4-trifluorophenyl)-5H-[1,2,4]triazolo[1,5-a]azepin-2-yl]-3-azabicyclo[3.2.1]octan-8-amine

参考文献

1. Hasane Ratni, et al. ACS Med Chem Lett. 2020 Apr 27;11(6):1257-1268.

RO7185876 (RO 7185876)

生物&药学活性

物理化学性质&存储条件

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RO7185876 (RO 7185876)

生物&药学活性

物理化学性质&存储条件

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