RO7075573 | Antibiotic | Probechem Biochemicals

Chemical Structure : RO7075573

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RO7075573 (RO 7075573)

货号: PC-21952Not For Human Use, Lab Use Only.

RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606.

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生物&药学活性

RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606.
RO7075573 exhibits vivo efficacy with 0.12 mg/L in mouse model of infection induced by A. baumannii ACC00535.
RO7075573 is 4- to 64-fold more potent than RO7036668 against a panel of A. baumannii, and displays selectivity against Acinetobacter (MIC > 64 mg/L).
RO7075573 is inactive against wild-type and efflux-impaired and porin-deficient Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.

物理化学性质&存储条件

分子量	739.76
分子式	C36H44Cl2N8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S,10S,13S)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-7-(3-aminopropyl)-17,20-dichloro-12-methyl-6,7,9,10,12,13,15,16-octahydrobenzo[b]pyrido[3,2-p][1]thia[5,8,11,14]tetraazacycloheptadecine-8,11,14(5H)-trione

参考文献

1. Claudia Zampaloni, et al. Nature. 2024 Jan;625(7995):566-571.

RO7075573 (RO 7075573)

生物&药学活性

物理化学性质&存储条件

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RO7075573 (RO 7075573)

生物&药学活性

物理化学性质&存储条件

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