RO5263397 | TAAR1 agonist | Probechem Biochemicals

Chemical Structure : RO5263397

CAS No.: 1357266-05-7

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RO5263397 (RO 5263397, RO-5263397)

货号: PC-61072Not For Human Use, Lab Use Only.

RO 5263397 is a highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TAAR1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

RO 5263397 is a highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TAAR1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor.
RO 5263397 shows EC50 of 35 nM for rat TRRA1.
RO 5263397 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine in vivo, does not induce catalepsy or weight gain, promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models.

物理化学性质&存储条件

分子量	194.209
分子式	C10H11FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine

参考文献

1. Revel FG, et al. Mol Psychiatry. 2013 May;18(5):543-56.

RO5263397 (RO 5263397, RO-5263397)

生物&药学活性

物理化学性质&存储条件

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RO5263397 (RO 5263397, RO-5263397)

生物&药学活性

物理化学性质&存储条件

参考文献

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