RO 5126946 | α7nAChR PAM | Probechem Biochemicals

Chemical Structure : RO 5126946

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RO 5126946 (RO5126946, RO-5126946)

货号: PC-60794Not For Human Use, Lab Use Only.

RO 5126946 is a potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.

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100 mg		Get quote

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生物&药学活性

RO 5126946 is a potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.
RO 5126946 shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors.
RO 5126946 enhances α7nAChR synaptic transmission and positively modulates GABAergic responses.
RO 5126946 improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.

物理化学性质&存储条件

分子量	408.897
分子式	C19H21ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamide

参考文献

1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68.

RO 5126946 (RO5126946, RO-5126946)

生物&药学活性

物理化学性质&存储条件

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RO 5126946 (RO5126946, RO-5126946)

生物&药学活性

物理化学性质&存储条件

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