RO 5126946 |CAS:1137233-79-4 Probechem Biochemicals

Chemical Structure : RO 5126946

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RO 5126946 (RO5126946;RO-5126946)

货号: PC-60794Not For Human Use, Lab Use Only.

A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.

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生物&药学活性

A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.

物理化学性质&存储条件

分子量	408.897
分子式	C19H21ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamide

参考文献

1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68.

RO 5126946 (RO5126946;RO-5126946)

生物&药学活性

物理化学性质&存储条件

参考文献

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RO 5126946 (RO5126946;RO-5126946)

生物&药学活性

物理化学性质&存储条件

参考文献

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