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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-γ-secretase-RO4929097
RO4929097

Chemical Structure : RO4929097

CAS No.: 847925-91-1

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RO4929097 (RG 4733;RO 4929097)

货号: PC-42810Not For Human Use, Lab Use Only.

RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM.
RO4929097 (RG 4733) displays >100-fold selectivity against a panel of 75 other proteins of various types including receptors, ion channels and enzymes.
RO4929097 (RG 4733) inhibits Notch processing in human tumor-derived cells, inhibits the production of ICN, reducing the expression of the downstream Notch target Hes1 in A549 cells.
RO4929097 (RG 4733) demonstrates in vivo efficacy in A549 xenograft model.

物理化学性质&存储条件

分子量 469.4045
分子式 C22H20F5N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 49 mg/mL
Chemical Name/SMILES

Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-

参考文献

1. Debeb BG, et al. Breast Cancer Res Treat. 2012 Jul;134(2):495-510.

2. Kaur G, et al. Cancer Lett. 2016 Feb 28;371(2):225-39.

3. He W, et al. Mol Oncol. 2011 Jun;5(3):292-301.

4. Luistro L, et al. Cancer Res. 2009 Oct 1;69(19):7672-80.

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