RO 28-2653 |CAS:261956-22-3 Probechem Biochemicals

Chemical Structure : RO 28-2653

加入收藏

RO 28-2653 (RO 282653)

货号: PC-63178Not For Human Use, Lab Use Only.

RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
RO 28-2653 reduces the growth of tumors induced by the inoculation of different cell lines producing MMPs and inhibits the tumor-promoting effect of fibroblasts on breast adenocarcinoma cells.
RO 28-2653 reduces tumor growth and prolongs survival in a prostate cancer standard rat model.

物理化学性质&存储条件

分子量	485.5
分子式	C26H23N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[1,1'-Biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione

参考文献

1. Abramjuk C, et al. Anticancer Drugs. 2005 Sep;16(8):855-61.

2. Maquoi E, et al. Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4038-47.

3. Mangoldt D, et al. Apoptosis. 2002 Jun;7(3):217-20.

4. Lein M, et al. Oncogene. 2002 Mar 27;21(13):2089-96.

RO 28-2653 (RO 282653)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RO 28-2653 (RO 282653)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.