RO1138452 | IP receptor inhibitor | Probechem Biochemicals

Chemical Structure : RO1138452

CAS No.: 221529-58-4

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RO1138452 (CAY10441, RO 1138452)

货号: PC-35353Not For Human Use, Lab Use Only.

RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

RO1138452 is a potent, selective antagonist of prostacyclin receptor (IP receptor), inhibits carbaprostacylin-stimulated c-AMP accumulation in human SH-SY5Y neuroblastoma cells with pKb of 8.8.
RO1138452 does not display significant affinity for cloned human EP1, EP3, FP, and TP receptors.
RO1138452 suppresses Taprostene (1 uM)-induced inhibition of CXCL9 and CXCL10 release from BEAS-2B cells with pA50 (molar) values of -8.73 and -8.47.

物理化学性质&存储条件

分子量	309.413
分子式	C19H23N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine

参考文献

1. Bley KR, et al. Br J Pharmacol. 2006 Feb;147(3):335-45.

2. Jones RL, et al. Br J Pharmacol. 2006 Sep;149(1):110-20.

3. Ayer LM, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26.

4. Clark RD, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1053-6.

RO1138452 (CAY10441, RO 1138452)

生物&药学活性

物理化学性质&存储条件

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RO1138452 (CAY10441, RO 1138452)

生物&药学活性

物理化学性质&存储条件

参考文献

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