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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-RO-9187
RO-9187

Chemical Structure : RO-9187

CAS No.: 876708-03-1

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RO-9187 (RO 9187, RO9187)

货号: PC-42722Not For Human Use, Lab Use Only.

RO-9187 is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 171 nM.

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5 mg ￥1780 In stock
10 mg ￥2880 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RO-9187 is a potent HCV NS5B RNA polymerase inhibitor,  inhibits HCV replication in the replicon system with IC50 of 171 nM.
RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=600-1100 nM).
RO-9187 shows good oral bioavailability in rats and no toxicologically significant findings.

物理化学性质&存储条件

分子量 284.2288
分子式 C9H12N6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-

参考文献

1. Klumpp K, et al. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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