RO-5963 |CAS:1416663-77-8 Probechem Biochemicals

Chemical Structure : RO-5963

CAS No.: 1416663-77-8

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RO-5963 (RO 5963;RO5963)

货号: PC-60443Not For Human Use, Lab Use Only.

RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.

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2 mg	￥2580	In stock
5 mg	￥4880	In stock
10 mg	￥7880	In stock
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100 mg		Get quote

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生物&药学活性

RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively.
RO-5963 stabilizes p53 and activates the p53 pathway in cancer cells, inhibits the binding of p53 to MDM2 and MDMX.
RO-5963 restores p53 transcriptional activity, elevates protein levels of its transcription targets, p21 and MDM2, and overcomes the apoptotic resistance of MDMX-overexpressing cell line, SJSA-X, to nutlin-3.
RO-5963 decreases cell viability and induces cell death.

物理化学性质&存储条件

分子量	518.902
分子式	C24H21ClF2N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(4-((6-Chloro-7-methyl-1H-indol-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamide

参考文献

1. Graves B, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.

RO-5963 (RO 5963;RO5963)

生物&药学活性

物理化学性质&存储条件

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RO-5963 (RO 5963;RO5963)

生物&药学活性

物理化学性质&存储条件

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