RO-5353 |Cas:1360821-61-9 Probechem Biochemicals

Chemical Structure : RO-5353

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RO-5353 (RO5353;RO 5353)

货号: PC-60304Not For Human Use, Lab Use Only.

RO-5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.

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生物&药学活性

RO-5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM.
RO-5353 exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994.
RO-5353 displays tumor regression in tumor models at 10 mg/kg.

物理化学性质&存储条件

分子量	619.533
分子式	C29H29Cl2FN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide

参考文献

1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.

RO-5353 (RO5353;RO 5353)

生物&药学活性

物理化学性质&存储条件

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RO-5353 (RO5353;RO 5353)

生物&药学活性

物理化学性质&存储条件

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