RO-275 | HCN1 inhibitor | Probechem Biochemicals

Chemical Structure : RO-275

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RO-275 (RO275, RO 275)

货号: PC-21477Not For Human Use, Lab Use Only.

RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.

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生物&药学活性

RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.
RO-275 also shows no activity against other ion channels, including hERG and Nav1.5.
RO-275 (3, 10, or 30 mg/kg i.p.) improves performance in a rodent working memory paradigm.
RO-275 (30 mg/kg) partially rescued performance impairment by MK-801.
RO-275 does not affect electrophysiological properties of hiPSC-derived atrial-like cardiomyocytes nor heart rate in rats.

物理化学性质&存储条件

分子量	351.79
分子式	C18H14ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide

参考文献

1. Harde E, et al. Cell Chem Biol. 2023 Nov 24:S2451-9456(23)00419-1.

RO-275 (RO275, RO 275)

生物&药学活性

物理化学性质&存储条件

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RO-275 (RO275, RO 275)

生物&药学活性

物理化学性质&存储条件

参考文献

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