Depulfavirine (RO-0335) | NNRTI | Probechem Biochemicals

Chemical Structure : RO-0335

CAS No.: 867365-76-2

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RO-0335 (Depulfavirine, RO 0335)

货号: PC-49139Not For Human Use, Lab Use Only.

RO-0335 is a highly potent, selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with IC50 of 8.1 nM, potently inhibits HIV replication with IC50 of 1.3 nM in cell based assays.

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10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5480	In stock
100 mg		Get quote
1 g		Get quote

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生物&药学活性

RO-0335 is a highly potent, selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with IC50 of 8.1 nM, potently inhibits HIV replication with IC50 of 1.3 nM in cell based assays.
RO-0335 shows potent inhibition of Wt HIV-1 with IC50 of 1.1 nM and retains activity (protein shifted IC50 < 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates.

物理化学性质&存储条件

分子量	573.214
分子式	C21H13BrCl2FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chloro-4-sulfamoylphenyl)acetamide

参考文献

1. H Javanbakht, et al. Antiviral Res. 2010 May;86(2):212-9.

RO-0335 (Depulfavirine, RO 0335)

生物&药学活性

物理化学性质&存储条件

参考文献

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RO-0335 (Depulfavirine, RO 0335)

生物&药学活性

物理化学性质&存储条件

参考文献

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