RNPA1000 | S. aureus RnpA inhibitor | Probechem Biochemicals

Chemical Structure : RNPA1000

CAS No.: 359600-10-5

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RNPA1000 (RNPA-1000)

货号: PC-43233Not For Human Use, Lab Use Only.

RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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生物&药学活性

RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.
RNPA1000 does not affect the activity of the E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at 750 uM.
RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus (S. aureus MRSA USA100 strain MIC=26 ug/mL) and protects against the S. aureus pathogenesis in an animal model of infection.

物理化学性质&存储条件

分子量	464.3113
分子式	C23H18BrN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]-

参考文献

1. Olson PD, et al. PLoS Pathog. 2011 Feb 10;7(2):e1001287.

2. Eidem TM, et al. J Biomater Appl. 2014 Apr;28(8):1235-46.

RNPA1000 (RNPA-1000)

生物&药学活性

物理化学性质&存储条件

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RNPA1000 (RNPA-1000)

生物&药学活性

物理化学性质&存储条件

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