RN486 | BTK inhibitor | Probechem Biochemicals

Chemical Structure : RN486

CAS No.: 1242156-23-5

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RN486 (RN-486)

货号: PC-45403Not For Human Use, Lab Use Only.

RN486 is a potent and selective BTK inhibitor with IC50 of 4 nM in enzymatic assays.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

RN486 is a potent and selective BTK inhibitor with IC50 of 4 nM in enzymatic assays.
RN486 shows high selectivity against a panel of 369 kinases.
RN486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC50=2.9 nM) and Fcγ receptor engagement-mediated TNFα production in monocytes (IC50=7.0 nM).
RN486 shows robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models.

物理化学性质&存储条件

分子量	606.6892
分子式	C35H35FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 24 mg/mL
Chemical Name/SMILES	1(2H)-Isoquinolinone, 6-cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro-

参考文献

1. Xu D, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103.

2. Mina-Osorio P, et al. Arthritis Rheum. 2013 Sep;65(9):2380-91.

3. Lou Y, et al. J Med Chem. 2015 Jan 8;58(1):512-6.

RN486 (RN-486)

生物&药学活性

物理化学性质&存储条件

参考文献

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RN486 (RN-486)

生物&药学活性

物理化学性质&存储条件

参考文献

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