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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-RN-9893 hydrochloride
RN-9893 hydrochloride

Chemical Structure : RN-9893 hydrochloride

CAS No.: 2109450-40-8

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RN-9893 hydrochloride (RN9893 hydrochloride)

货号: PC-70040Not For Human Use, Lab Use Only.

RN-9893 hydrochloride is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RN-9893 hydrochloride is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.
    RN-9893 dispalys >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.

    物理化学性质&存储条件

    分子量 536.95
    分子式 C21H23F3N4O5S.HCl
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((4-isopropylpiperazin-1-yl)sulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

    参考文献

    1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

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