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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-RN-9893
RN-9893

Chemical Structure : RN-9893

CAS No.: 1803003-68-0

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RN-9893 (RN9893;RN 9893)

货号: PC-70039Not For Human Use, Lab Use Only.

RN-9893 (RN9893) is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RN-9893 (RN9893) is a potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively.
RN-9893 shows >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.

物理化学性质&存储条件

分子量 500.493
分子式 C21H23F3N4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((4-isopropylpiperazin-1-yl)sulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide

参考文献

1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.

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