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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-RN-18
RN-18

Chemical Structure : RN-18

CAS No.: 431980-38-0

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RN-18 (Vif inhibitor RN-18)

货号: PC-62712Not For Human Use, Lab Use Only.

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G.

规格 价格 库存 数量
25 mg (4 weeks) ￥2880 In stock
100 mg (4 weeks) ￥4780 In stock
250 mg (4 weeks) ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RN-18 is a small molecule that antagonizes HIV-1 Vif function and inhibits HIV-1 replication only in the presence of A3G; increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation; enhances Vif degradation, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.

物理化学性质&存储条件

分子量 380.418
分子式 C20H16N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-Methoxyphenyl)-2-[(4-nitrophenyl)thio]benzamide

参考文献

1. Nathans R, et al. Nat Biotechnol. 2008 Oct;26(10):1187-92.

2. Mohammed I, et al. J Med Chem. 2016 Aug 25;59(16):7677-82.

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