RN-1734 |CAS:946387-07-1 Probechem Biochemicals

Chemical Structure : RN-1734

CAS No.: 946387-07-1

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RN-1734 (RN1734;RN 1734)

货号: PC-45772Not For Human Use, Lab Use Only.

RN-1734 (RN1734) is a potent, selective TRPV4 antagonist with IC50 of 2.3, 3.2 and 5.9 uM for hTRPV4, rTRPV4 and mTRPV4 channels, respectively.

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

RN-1734 (RN1734) is a potent, selective TRPV4 antagonist with IC50 of 2.3, 3.2 and 5.9 uM for hTRPV4, rTRPV4 and mTRPV4 channels, respectively.
RN-1734 displays selectivity for TRPV4 over other TRP channels (TRPV3, TRPM8 and TRPV1).
RN-1734 reduces the H2O2-induced vasorelaxation in porcine isolated coronary arteries.

物理化学性质&存储条件

分子量	353.3077
分子式	C14H22Cl2N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-

参考文献

1. Vincent F, et al. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.

2. Bagher P, et al. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18174-9.

3. Wong PS, et al. Eur J Pharmacol. 2015 Mar 5;750:108-17.

RN-1734 (RN1734;RN 1734)

生物&药学活性

物理化学性质&存储条件

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RN-1734 (RN1734;RN 1734)

生物&药学活性

物理化学性质&存储条件

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