RMS-07 |CAS:2645409-78-3 Probechem Biochemicals

Chemical Structure : RMS-07

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RMS-07 (RMS07)

货号: PC-38336Not For Human Use, Lab Use Only.

RMS-07 (RMS 07) is the first potent, selective irreversible covalent inhibitor of Monopolar spindle kinase 1 (MPS1/TTK) with IC50 of 13 nM, Ki of 0.83 nM.

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生物&药学活性

RMS-07 (RMS 07) is the first potent, selective irreversible covalent inhibitor of Monopolar spindle kinase 1 (MPS1/TTK) with IC50 of 13 nM, Ki of 0.83 nM.
RMS-07 demonstrated intracellular target engagement with IC50 of 22.4 nM, shows a high selectivity against MAPKAPK2/3, FGFR4, p70S6Kβ (IC50>1 uM).
RMS-07 induced cell cycle arrest with a prolonged G2/M phase, downregulated cyclin B1, whereas it upregulated p53, p21, and phospho-γH2A.X, enhanced cleaved PARP levels; RMS-07 attenuates cancer cell proliferation.
RMS-07 and Navitoclax synergistically inhibit hepatocellular carcinoma cell proliferation.

物理化学性质&存储条件

分子量	604.759
分子式	C35H40N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-{[2-Acrylamido-4-(4-methylpiperazin-1-yl)phenyl]amino}-N-(2,6-diethylphenyl)-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide

参考文献

1. Ricardo A M Serafim, et al. J Med Chem. 2022 Feb 15.

RMS-07 (RMS07)

生物&药学活性

物理化学性质&存储条件

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RMS-07 (RMS07)

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