RMC-6236 | Ras inhibitor | Probechem Biochemicals

Chemical Structure : RMC-6236

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RMC-6236 (RMC6236)

货号: PC-22125Not For Human Use, Lab Use Only.

RMC-6236 is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants.

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生物&药学活性

RMC-6236 is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants.
RMC-6236 exhibits potent anticancer activity across RAS-addicted cell lines, particularly those harboring mutations at codon 12 of KRAS.
Oral administration of RMC-6236 is tolerated in vivo and drives profound tumor regressions across multiple tumor types in a mouse clinical trial with KRASG12X xenograft models.

物理化学性质&存储条件

分子量	811.06
分子式	C44H58N8O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-N-((63S,4S,Z)-11-ethyl-12-(2-((S)-1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)-2-methylcyclopropane-1-carboxamide

参考文献

1. Jiang J, et al. Cancer Discov. 2024 Apr 9:OF1-OF24.

RMC-6236 (RMC6236)

生物&药学活性

物理化学性质&存储条件

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RMC-6236 (RMC6236)

生物&药学活性

物理化学性质&存储条件

参考文献

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