RM-3-22

Chemical Structure : RM-3-22

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货号: PC-24921Not For Human Use, Lab Use Only.

RM-3-22 is a TAZQ-based hydroxamic acid derivative and potent HDAC inhibitor with IC50 of 49.9 nM, 68.5 nM, and 12.9 nM for HDAC1, HDAC3, and HDAC6 isoforms respectively.

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100 mg		Get quote

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生物&药学活性

RM-3-22 is a TAZQ-based hydroxamic acid derivative and potent HDAC inhibitor with IC50 of 49.9 nM, 68.5 nM, and 12.9 nM for HDAC1, HDAC3, and HDAC6 isoforms respectively.
RM-3-22 displays 97, 126-, 47-, 316-, and 334-folds higher selectivity towards HDAC6 isoform in comparison to HDAC2, HDAC4, HDAC5, HDAC7, and HDAC9, respectively.
RM-3-22 induces the cytotoxicity of different cancer cell lines, especially the lung cancer cell line A549 (IC50=0.8 uM).
RM-3-22 induces autophagy pathway through the inhibition of PI3K/Akt/mTOR.
RM-3-22 significantly induces caspase-dependent apoptosis in A549 cells.
RM-3-22 treatment causes cell cycle arrest in the G2/M phase by the disruption of cyclin B and CDC2 in A549 cells.
RM-3-22 enhances the expression of the tumor suppressor gene FTH1, which is positively correlated with apoptosis and autophagy pathway.
RM-3-22 suppresses tumor growth by inducing autophagy, apoptosis, cell cycle arrest, and FTH1 upregulation.

物理化学性质&存储条件

分子量	404.47
分子式	C23H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-hydroxy-3-(4-(((12-oxo-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-2-yl)amino)methyl)phenyl)acrylamide

参考文献

1. Sharma R, et al. Eur J Med Chem. 2022 Oct 5;240:114602.

2. Chatterjee E, et al. Front Pharmacol. 2025 Jun 5;16:1544666.

RM-3-22

生物&药学活性

物理化学性质&存储条件

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RM-3-22

生物&药学活性

物理化学性质&存储条件

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