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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Myosin-RLC-1
RLC-1

Chemical Structure : RLC-1

CAS No.:

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RLC-1

货号: PC-28306Not For Human Use, Lab Use Only.

RLC-1 is a specific cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC), inhibits ATPase in bovine cardiac heavy meromyosin (HMM), but not when RLC is removed.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RLC-1 is a specific cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC), inhibits ATPase in bovine cardiac heavy meromyosin (HMM), but not when RLC is removed.
RLC-1 inhibits force production in both myofibrils and demembranated trabeculae in ex vivo studies.
RLC-1 also moves myosin heads away from the thick filament backbone and accelerates steady-state and dynamic contractile kinetics. inhibits the
interaction between myosin and actin, reduces contractile force
development and Ca2+ sensitivity of force, and increases the
submaximal rate constant for tension redevelopment.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Kooiker K, et al. J Gen Physiol. 2024 Oct 7;156(10):e202313503.

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