RK-33 | DDX3 inhibitor | Probechem Biochemicals

Chemical Structure : RK-33

CAS No.: 1070773-09-9

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RK-33 (DDX3 inhibitor RK-33, RK33)

货号: PC-61320Not For Human Use, Lab Use Only.

RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

RK-33 is a first-in-class small molecule inhibitor of RNA helicase DDX3, binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17.
RK-33 causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
RK-33 exhibits growth inhibitory properties against NCI-60 panel of cell lines with GI50 of <1 uM-7 uM.
RK-33 inhibits Wnt signaling mediated by DDX3, and promotes tumor regression in preclinical models of DDX3-overexpressing lung cancer in combination with radiation.

物理化学性质&存储条件

分子量	428.44
分子式	C23H20N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,7-Dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

参考文献

1. Bol GM, et al. EMBO Mol Med. 2015 May;7(5):648-69.

2. Kondaskar A, et al. ACS Med Chem Lett. 2010 Dec 31;2(3):252-256.

3. Heerma van Voss MR, et al. Oncotarget. 2015 Sep 29;6(29):28312-26.

RK-33 (DDX3 inhibitor RK-33, RK33)

生物&药学活性

物理化学性质&存储条件

参考文献

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RK-33 (DDX3 inhibitor RK-33, RK33)

生物&药学活性

物理化学性质&存储条件

参考文献

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