RJR-2403 oxalate |CAS:220662-95-3 Probechem Biochemicals

Chemical Structure : RJR-2403 oxalate

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RJR-2403 oxalate ((E)-Metanicotine oxalate;Rivanicline oxalate;RJR 2403 oxalate)

货号: PC-43404Not For Human Use, Lab Use Only.

规格	价格	库存	数量
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100 mg		Get quote

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生物&药学活性

RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors; RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes with EC50 of 732 nM; significantly improves passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats, also demonstrates greatly reduced cardiovascular effects; exerts its antinociceptive effect via nicotinic rather than either opioid or muscarinic mechanisms.

物理化学性质&存储条件

分子量	252.2664
分子式	C12H16N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in H2O
Chemical Name/SMILES	3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-, ethanedioate (1:1) (9CI)

参考文献

1. Bencherif M, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.

2. Lippiello PM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.

3. Damaj MI, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.

4. Ueno K, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):95-100.

RJR-2403 oxalate ((E)-Metanicotine oxalate;Rivanicline oxalate;RJR 2403 oxalate)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

RJR-2403 oxalate ((E)-Metanicotine oxalate;Rivanicline oxalate;RJR 2403 oxalate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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